Training

Is it right for me?

• This highly interdisciplinary course in next-generation publicly available chemoinformatics tools is ideal for academics or industrial researchers interested in drug discovery or for researchers looking to progress from basic functional genomics to translational research.
• Participants should have a degree in a biomedical discipline. No previous training in bioinformatics is required.
• The course will be highly interactive and will include problem solving sessions each day. Attendees are strongly encouraged to bring ideas for particular pieces of work to the addressed during these sessions.

What will I learn?

• Searching of public databases such as ChEMBL and PubChem, for small molecules of biological interest.
• Using related bioinformatics databases and services (including Ensembl, Uniprot, ArrayExpress and Zinc), to cross-reference small molecule data.
• Investigate the structure-activity relationships of small bioactive molecules using ChEMBL.
• Selecting compounds to screen against novel targets and reference standards.
• Optimising compound structures for target validation.

What will it cover?

• Overview of public domain chemical structure resources.
• The role of open science in drug discovery.
• Analysis and modulation of disease linked pathways.
• Tools and strategies to get the best from chemical and small molecule databases.
• Target analysis and prioritisation of genomic data for drug discovery.