EMBL International PhD Programme - PhD bioinformatics projects available at the EBI

Alvis Brazma:

Microarray informatics

Alvis’s team is responsible for the development of the ArrayExpress resource for gene expression and related functional genomics data. In addition, the group’s research focuses on the integration and meta-analysis of different data sets, including genomics and medical data, with the goal of understanding and modelling basic biological processes or diagnostics. Other research activities include high-throughput data analysis and development of algorithms for systems biology and biomedical informatics research.

Nick Goldman:

Evolutionary analysis of sequence data

Nick’s group is developing better methods for analysing DNA and amino acid sequences to study evolution, and uses information from evolutionary studies to improve other data analyses in bioinformatics. Their work includes the theoretical basis of phylogenetic analyses of sequence data. They also focus on devising better mathematical models to describe sequence evolution. By seeing which biological features add most to the accuracy of the models, they hope to find out which proposed evolutionary forces are responsible for the patterns of sequence variation within and among species

Julio Saez-Rodriguez

The group is interested in how the dynamics of signal transduction ultimately influence cell fate decisions. Specifically, the group’s research aims to combine statistical methods with models describing the mechanisms of signal transduction either as logical or physico-chemical systems. They then use these models to better understand how signalling is altered in human disease and predict effective therapeutic targets.