M-CSA Mechanism and Catalytic Site Atlas

Alkaline phosphatase (M-CSA:44)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P00634

Reference Sequence	Homologue	Arg188 Thr177 Glu344 Asp349 His353 Asp391 His392 His434 Asp175 Ser124 Lys350 Asp73
P00634	P00634	Arg188 Thr177 Glu344 Asp349 His353 Asp391 His392 His434 Asp175 Ser124 Lys350 Asp73
P00634	P35483	Arg192 Thr181 Glu348 Asp353 His357 Asp395 His396 His438 Asp179 Ser128 Lys354 Asp77
P00634	P24822	Arg185 Ser174 Glu330 Asp335 His339 Asp376 His377 His450 His172 Ser111 Arg336 Asp61
P00634	P08289	Arg184 Thr173 Glu332 Asp337 His341 Asp378 His379 His454 His171 Ser110 His338 Asp60
P00634	P19111	Arg185 Ser174 Glu330 Asp335 His339 Asp376 His377 His451 His172 Ser111 His336 Asp61
P00634	P51740	Ser185 Ser174 Glu330 Asp335 His339 Asp376 His377 Thr450 His172 Ser111 Arg336 Asp61
P00634	Q29486	Arg184 Thr173 Glu332 Asp337 His341 Asp378 His379 His454 His171 Ser110 His338 Asp60
P00634	P19406	Arg172 Thr161 Glu282 Asp287 His291 Asp329 His330 His423 His159 Ser108 Trp288 Asp58
P00634	P10696	Arg185 Ser174 Glu330 Asp335 His339 Asp376 His377 His451 His172 Ser111 His336 Asp61
P00634	P24823	Arg184 Ser173 Glu329 Asp334 His338 Asp375 His376 His450 His171 Ser110 His335 Asp60
P00634	P09242	Arg184 Thr173 Glu332 Asp337 His341 Asp378 His379 His454 His171 Ser110 His338 Asp60
P00634	Q92058	Arg183 Thr172 Glu331 Asp336 His340 Asp377 His378 His453 His170 Ser109 His337 Asp59
P00634	P11491	Arg187 Thr176 Glu325 Asp330 His334 Asp373 His374 His484 Asp174 Ser123 His331 Asp75
P00634	P05186	Arg184 Thr173 Glu332 Asp337 His341 Asp378 His379 His454 His171 Ser110 His338 Asp60
P00634	P19405	Arg165 Thr154 Glu275 Asp280 His284 Asp322 His323 His419 His152 Ser101 Trp281 Asp52
P00634	P09487	Arg184 Thr173 Glu332 Asp337 His341 Asp378 His379 His454 His171 Ser110 His338 Asp60
P00634	O60109	Arg179 Thr168 Glu306 Asp311 His315 Asp352 His353 His456 Asp166 Ser115 Met312 Asp68
P00634	P15693	Arg186 Ser175 Glu331 Asp336 His340 Asp377 His378 His452 His173 Ser112 Gln337 Asp62
P00634	P29523	Arg209 Ser198 Glu356 Asp361 His365 Asp402 His403 His479 His196 Ser133 His362 Asp83
P00634	Q24238	Arg215 Thr204 Glu369 Asp374 His378 Asp415 His416 His504 His202 Ser144 Gln375 Asp93
P00634	P05187	Arg188 Ser177 Glu333 Asp338 His342 Asp379 His380 His454 His175 Ser114 His339 Asp64
P00634	P09923	Arg185 Ser174 Glu330 Asp335 His339 Asp376 His377 His451 His172 Ser111 His336 Asp61
P00634	P09401	Arg164 Thr153 Glu321 Asp326 His330 Asp368 His369 His412 Asp151 Ser99 Asp327 Asp50
P00634	P19147	Arg192 Thr181 Glu348 Asp353 His357 Asp395 His396 His438 Asp179 Ser128 Lys354 Asp77
P00634	P21948	Arg189 Thr178 Glu345 Asp350 His354 Asp392 His393 His435 Asp176 Ser125 Lys351 Asp74
P00634	Q02QC9	Arg192 Thr181 Glu348 Asp353 His357 Asp395 His396 His438 Asp179 Ser128 Lys354 Asp77
P00634	P83456	Arg168 Thr157 Glu315 Asp320 His324 Asp361 His362 His437 His155 Ser94 His321 Asp44