M-CSA Mechanism and Catalytic Site Atlas

Mannosyl-oligosaccharide 1,2-alpha-mannosidase (M-CSA:19)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of Q9UKM7, P32906

Reference Sequence	Homologue	Glu132 Asp275 Arg136 Glu330 Arg334 Asp463 Glu599 Glu435
P32906	A1D1W1	Glu114 Asp259 Arg118 Glu114 Arg118 Asp259 Glu401 Glu401
P32906	P32906	Glu132 Asp275 Arg136 Glu132 Arg136 Asp275 Glu435 Glu435
P32906	A1CP08	Glu117 Asp262 Arg121 Glu117 Arg121 Asp262 Glu404 Glu404
P32906	A2AJ15	Glu289 Asp422 Arg293 Glu289 Arg293 Asp422 Glu558 Glu558
P32906	A2QAS2	Glu124 Asp269 Arg128 Glu124 Arg128 Asp269 Glu411 Glu411
P32906	B0XMT4	Glu114 Asp259 Arg118 Glu114 Arg118 Asp259 Glu401 Glu401
P32906	B2GUY0	Glu288 Asp421 Arg292 Glu288 Arg292 Asp421 Glu557 Glu557
P32906	B8N417	Glu122 Asp267 Arg126 Glu122 Arg126 Asp267 Glu409 Glu409
P32906	D4AV26	Glu122 Asp266 Arg126 Glu122 Arg126 Asp266 Glu408 Glu408
P32906	E9CXX8	Glu127 Asp272 Arg131 Glu127 Arg131 Asp272 Glu414 Glu414
P32906	O02773	Glu286 Asp419 Arg290 Glu286 Arg290 Asp419 Glu553 Glu553
P32906	O60476	Glu266 Asp399 Arg270 Glu266 Arg270 Asp399 Glu533 Glu533
P32906	O94726	Glu130 Asp270 Arg134 Glu130 Arg134 Asp270 Glu384 Glu384
P32906	P31723	Glu122 Asp267 Arg126 Glu122 Arg126 Asp267 Glu409 Glu409
P32906	P33908	Glu280 Asp413 Arg284 Glu280 Arg284 Asp413 Glu547 Glu547
P32906	P38888	Glu133 Asp279 Arg137 Glu133 Arg137 Asp279 Glu409 Glu409
P32906	P39098	Glu266 Asp399 Arg270 Glu266 Arg270 Asp399 Glu533 Glu533
P32906	P45700	Glu282 Asp415 Arg286 Glu282 Arg286 Asp415 Glu549 Glu549
P32906	P45701	Glu96 Asp229 Arg100 Glu96 Arg100 Asp229 Glu363 Glu363
P32906	P53624	Glu287 Asp420 Arg291 Glu287 Arg291 Asp420 Glu554 Glu554
P32906	Q0D076	Glu121 Asp266 Arg125 Glu121 Arg125 Asp266 Glu408 Glu408
P32906	Q12563	Glu124 Asp269 Arg128 Glu124 Arg128 Asp269 Glu411 Glu411
P32906	Q18788	Glu226 Asp359 Arg230 Glu226 Arg230 Asp359 Glu494 Glu494
P32906	Q2HXL6	Glu147 Asp294 Arg151 Glu147 Arg151 Asp294 Glu406 Glu406
P32906	Q2ULB2	Glu122 Asp267 Arg126 Glu122 Arg126 Asp267 Glu409 Glu409
P32906	Q4WRZ5	Glu114 Asp259 Arg118 Glu114 Arg118 Asp259 Glu401 Glu401
P32906	Q5BF93	Glu115 Asp259 Arg119 Glu115 Arg119 Asp259 Glu402 Glu402
P32906	Q6GQB9	Glu132 Asp279 Arg136 Glu132 Arg136 Asp279 Glu391 Glu391
P32906	Q8BJT9	Glu117 Asp258 Arg121 Glu117 Arg121 Asp258 Glu372 Glu372
P32906	Q8H116	Glu180 Asp312 Arg184 Glu180 Arg184 Asp312 Glu446 Glu446
P32906	Q8J0Q0	Glu121 Asp253 Arg125 Glu121 Arg125 Asp253 Glu406 Glu406
P32906	Q925U4	Glu220 Asp365 Arg224 Glu220 Arg224 Asp365 Glu488 Glu488
P32906	Q92611	Glu225 Asp370 Arg229 Glu225 Arg229 Asp370 Glu493 Glu493
P32906	Q93Y37	Glu212 Asp357 Arg216 Glu212 Arg216 Asp357 Glu526 Glu526
P32906	Q9BV94	Glu117 Asp258 Arg121 Glu117 Arg121 Asp258 Glu372 Glu372
P32906	Q9BZQ6	Glu146 Asp293 Arg150 Glu146 Arg150 Asp293 Glu405 Glu405
P32906	Q9C512	Glu179 Asp312 Arg183 Glu179 Arg183 Asp312 Glu445 Glu445
P32906	Q9FG93	Glu122 Asp262 Arg126 Glu122 Arg126 Asp262 Glu376 Glu376
P32906	Q9NR34	Glu259 Asp390 Arg263 Glu259 Arg263 Asp390 Glu524 Glu524
P32906	Q9P7C3	Glu130 Asp263 Arg134 Glu130 Arg134 Asp263 Glu414 Glu414
P32906	Q9SXC9	Glu134 Asp274 Arg138 Glu134 Arg138 Asp274 Glu388 Glu388
P32906	Q9UKM7	Glu330 Asp463 Arg334 Glu330 Arg334 Asp463 Glu599 Glu599
Q9UKM7	Q9UKM7	Glu330 Asp463 Arg334 Glu330 Arg334 Asp463 Glu599 Glu599
Q9UKM7	A1CP08	Glu117 Asp262 Arg121 Glu117 Arg121 Asp262 Glu404 Glu404
Q9UKM7	A1D1W1	Glu114 Asp259 Arg118 Glu114 Arg118 Asp259 Glu401 Glu401
Q9UKM7	A2AJ15	Glu289 Asp422 Arg293 Glu289 Arg293 Asp422 Glu558 Glu558
Q9UKM7	A2QAS2	Glu124 Asp269 Arg128 Glu124 Arg128 Asp269 Glu411 Glu411
Q9UKM7	B0XMT4	Glu114 Asp259 Arg118 Glu114 Arg118 Asp259 Glu401 Glu401
Q9UKM7	B2GUY0	Glu288 Asp421 Arg292 Glu288 Arg292 Asp421 Glu557 Glu557
Q9UKM7	B8N417	Glu122 Asp267 Arg126 Glu122 Arg126 Asp267 Glu409 Glu409
Q9UKM7	D4AV26	Glu122 Asp266 Arg126 Glu122 Arg126 Asp266 Glu408 Glu408
Q9UKM7	E9CXX8	Glu127 Asp272 Arg131 Glu127 Arg131 Asp272 Glu414 Glu414
Q9UKM7	O02773	Glu286 Asp419 Arg290 Glu286 Arg290 Asp419 Glu553 Glu553
Q9UKM7	O60476	Glu266 Asp399 Arg270 Glu266 Arg270 Asp399 Glu533 Glu533
Q9UKM7	O94726	Glu130 Asp270 Arg134 Glu130 Arg134 Asp270 Glu384 Glu384
Q9UKM7	P31723	Glu122 Asp267 Arg126 Glu122 Arg126 Asp267 Glu409 Glu409
Q9UKM7	P32906	Glu132 Asp275 Arg136 Glu132 Arg136 Asp275 Glu435 Glu435
Q9UKM7	P33908	Glu280 Asp413 Arg284 Glu280 Arg284 Asp413 Glu547 Glu547
Q9UKM7	P38888	Glu133 Asp279 Arg137 Glu133 Arg137 Asp279 Glu409 Glu409
Q9UKM7	P39098	Glu266 Asp399 Arg270 Glu266 Arg270 Asp399 Glu533 Glu533
Q9UKM7	P45700	Glu282 Asp415 Arg286 Glu282 Arg286 Asp415 Glu549 Glu549
Q9UKM7	P45701	Glu96 Asp229 Arg100 Glu96 Arg100 Asp229 Glu363 Glu363
Q9UKM7	P53624	Glu287 Asp420 Arg291 Glu287 Arg291 Asp420 Glu554 Glu554
Q9UKM7	Q0D076	Glu121 Asp266 Arg125 Glu121 Arg125 Asp266 Glu408 Glu408
Q9UKM7	Q12205	X X X Asp239 Arg243 Asn418 Asn751 X
Q9UKM7	Q12563	Glu124 Asp269 Arg128 Glu124 Arg128 Asp269 Glu411 Glu411
Q9UKM7	Q18788	Glu226 Asp359 Arg230 Glu226 Arg230 Asp359 Glu494 Glu494
Q9UKM7	Q2HXL6	Glu147 Asp294 Arg151 Glu147 Arg151 Asp294 Glu406 Glu406
Q9UKM7	Q2ULB2	Glu122 Asp267 Arg126 Glu122 Arg126 Asp267 Glu409 Glu409
Q9UKM7	Q4WRZ5	Glu114 Asp259 Arg118 Glu114 Arg118 Asp259 Glu401 Glu401
Q9UKM7	Q5BF93	Glu115 Asp259 Arg119 Glu115 Arg119 Asp259 Glu402 Glu402
Q9UKM7	Q92611	Glu225 Asp370 Arg229 Glu225 Arg229 Asp370 Glu493 Glu493
Q9UKM7	Q6GQB9	Glu132 Asp279 Arg136 Glu132 Arg136 Asp279 Glu391 Glu391
Q9UKM7	Q8BJT9	Glu117 Asp258 Arg121 Glu117 Arg121 Asp258 Glu372 Glu372
Q9UKM7	Q8H116	Glu180 Asp312 Arg184 Glu180 Arg184 Asp312 Glu446 Glu446
Q9UKM7	Q8J0Q0	Glu121 Asp253 Arg125 Glu121 Arg125 Asp253 Glu406 Glu406
Q9UKM7	Q925U4	Glu220 Asp365 Arg224 Glu220 Arg224 Asp365 Glu488 Glu488
Q9UKM7	Q93Y37	Glu212 Asp357 Arg216 Glu212 Arg216 Asp357 Glu526 Glu526
Q9UKM7	Q9BV94	Glu117 Asp258 Arg121 Glu117 Arg121 Asp258 Glu372 Glu372
Q9UKM7	Q9BZQ6	Glu146 Asp293 Arg150 Glu146 Arg150 Asp293 Glu405 Glu405
Q9UKM7	Q9C512	Glu179 Asp312 Arg183 Glu179 Arg183 Asp312 Glu445 Glu445
Q9UKM7	Q9FG93	Glu122 Asp262 Arg126 Glu122 Arg126 Asp262 Glu376 Glu376
Q9UKM7	Q9NR34	Glu259 Asp390 Arg263 Glu259 Arg263 Asp390 Glu524 Glu524
Q9UKM7	Q9P7C3	Glu130 Asp263 Arg134 Glu130 Arg134 Asp263 Glu414 Glu414
Q9UKM7	Q9SXC9	Glu134 Asp274 Arg138 Glu134 Arg138 Asp274 Glu388 Glu388