M-CSA Mechanism and Catalytic Site Atlas

Cytochrome-c3 hydrogenase (M-CSA:126)

Proteins that are close homologues to the M-CSA reference protein and have the same catalytic residues (highlighted in green, below) probably share the same mechanism. Please also check if the homologue shares the same FunTree Structural Cluster and the same Pfam family, as another measure of similarity.

Legend:
Reference Residue Conserved Residue Non Conserved Residue Outside Alignment Reference Residue not in this sequence

Homologous SwissProt sequences of P12944

Reference Sequence	Homologue	Arg463 Ser486 Cys530 Cys533 Glu18 Cys65 Cys68 His72
P12944	P12944	Arg463 Ser486 Cys530 Cys533 Glu18 Cys65 Cys68 His72
P12944	P21852	Arg479 Ser502 Cys546 Cys549 Glu34 Cys81 Cys84 His88
P12944	P13065	Arg426 Thr449 Sec493 Cys496 Glu24 Cys71 Cys74 His78
P12944	Q60338	Arg338 Ser362 Cys391 Cys394 Glu19 Cys68 Cys71 His75
P12944	P0ACE0	Arg479 Ser502 Cys546 Cys549 Glu14 Cys61 Cys64 His68
P12944	P84625	Arg387 Thr411 Cys454 Cys457 Glu13 Cys61 Cys64 His68
P12944	P31891	Arg530 Thr553 Cys597 Cys600 Glu27 Cys75 Cys78 His82
P12944	P12636	Arg508 Thr531 Cys575 Cys578 Glu27 Cys75 Cys78 His82
P12944	P0ACD8	Arg509 Thr532 Cys576 Cys579 Glu28 Cys76 Cys79 His83
P12944	Q58592	Arg374 Thr398 not aligned not aligned Glu13 Cys61 Cys64 His68
P12944	O33406	Arg516 Thr539 Cys583 Cys586 Glu28 Cys76 Cys79 His83
P12944	E7FHC4	Arg338 Thr361 Cys402 Cys405 Glu12 Cys60 Cys63 His67
P12944	P22320	Arg391 Thr415 Cys458 Cys461 Glu14 Cys62 Cys65 His69
P12944	P31883	Arg480 Ser503 Cys547 Cys550 Glu14 Cys62 Cys65 His69
P12944	Q50783	Arg375 Thr399 Cys442 Cys445 Glu13 Cys61 Cys64 His68
P12944	P19496	Arg328 Thr351 Cys380 Cys383 Glu14 Cys63 Cys66 His70
P12944	P18188	Arg476 Ser499 Cys543 Cys546 Glu25 Cys72 Cys75 His79
P12944	P0ACD9	Arg509 Thr532 Cys576 Cys579 Glu28 Cys76 Cys79 His83
P12944	P80489	Arg380 Thr403 Cys432 Cys435 Glu14 Cys63 Cys66 His70
P12944	P18636	Arg508 Thr531 Cys575 Cys578 Glu27 Cys75 Cys78 His82
P12944	Q49179	Arg375 Thr399 Cys442 Cys445 Glu13 Cys61 Cys64 His68
P12944	Q00404	Arg378 Thr402 Cys445 Cys448 Glu13 Cys61 Cys64 His68
P12944	P0ACE1	Arg479 Ser502 Cys546 Cys549 Glu14 Cys61 Cys64 His68
P12944	P15284	Arg509 Thr532 Cys576 Cys579 Glu27 Cys75 Cys78 His82
P12944	P18191	Arg513 Thr536 Cys580 Cys583 Glu26 Cys74 Cys77 Thr81
P12944	Q00390	Arg334 Thr358 Cys386 Cys389 Glu14 Cys63 Cys66 His70
P12944	Q46046	Arg509 Thr532 Cys576 Cys579 Glu28 Cys76 Cys79 His83
P12944	P21949	Arg514 Thr537 Cys581 Cys584 Glu26 Cys74 Cys77 His81
P12944	P17632	Arg530 Thr553 Cys597 Cys600 Glu27 Cys75 Cys78 His82
P12944	Q00407	Arg374 Thr398 not aligned not aligned Glu13 Cys61 Cys64 His68
P12944	P0ACE2	Arg479 Ser502 Cys546 Cys549 Glu14 Cys61 Cys64 His68
P12944	P60227	Arg375 Thr399 Cys442 Cys445 Glu13 Cys61 Cys64 His68
P12944	P33374	Arg533 Thr556 Cys600 Cys603 Glu27 Cys75 Cys78 His82