ProFunc Prediction of protein function from 3D structure
The aim of the ProFunc server is to help identify the likely biochemical function of a protein from its three-dimensional structure. It uses a series of methods, including fold matching, residue conservation, surface cleft analysis, and functional 3D templates, to identify both the protein's likely active site and possible homologues in the PDB.
From this page you can submit your own structure, analyse an existing PDB entry, or retrieve the results of a previously submitted run.
Choose option A, B or C:
Runs ProFunc on an existing PDB entry or, if already done, takes you directly to the results page.
Some of the methods take minutes to run; others take hours. You will be notified by e-mail when the entire process is complete, but can check on preliminary results as they become available.
The files are usually stored for about 6 months before being deleted. However, they are stored on a partition that is not backed up; so, in principle, they could disappear at any time.
ProFunc has been developed jointly with the Midwest Center for Structural Genomics (MCSG)
Structural analyses of all PDB entries
Customized 3D template generation from submitted structure and search vs PDB.