Pattern PS00141
ASP_PROTEASE
[LIVMFGAC]-[LIVMTADN]-[LIVFSA]-D-[ST]-G-[STAV]-[STAPDENQ]-{GQ}-[LIVMFSTNC]-{EGK}-[LIVMFGTA]
The following PDB entries contain known "true positive" matches for this PROSITE pattern, or matches that are highly likely to be correct.
1 | 26 | 51 | 76

.PDB..Code
Title
1b11  Structure of feline immunodeficiency virus protease complexe 3- 093
1e81  Endothiapepsin complex with renin inhibitor merck- kgaa- emd61
1er8  The active site of aspartic proteinases
1hpv  Crystal structure of HIV- 1 protease in complex with vx- 478, and orally bioavailable inhibitor of the enzyme
1t7j  Crystal structure of inhibitor amprenavir in complex with a resistant variant of HIV- 1 protease (l63p/v82t/i84v)
2fxe  X- ray crystal structure of HIV- 1 protease crm mutant complex atazanavir (bms- 232632)
2hah  The structure of fiv 12s protease in complex with tl- 3
2i4q  Human renin/pf02342674 complex
2nmw  Crystal structure analysis of HIV- 1 protease with a inhibito saquinavir
2r9b  Structural analysis of plasmepsin 2 from plasmodium falcipar complexed with a peptide- based inhibitor
2vj6  Human bace- 1 in complex with n- ((1s,2r)- 3- (((1s)- 2- ( cyclohexylamino)- 1- methyl- 2- oxoethyl)amino)- 2- hydroxy- 1- ( phenylmethyl)propyl)- 3- (ethylamino)- 5- (2- oxo- 1- pyrrolidinyl)benzamide
2whh  HIV- 1 protease tethered dimer q- product complex along with nucleophilic water molecule
2wjo  Human bace (beta secretase) in complex with cyclohexanecarboxylic acid (2- (2- am ino- 6- phenoxy- 4h- quinazolin- 3- yl)- 2- cyclohexyl- ethyl)- amide
2x0b  Crystal structure of human angiotensinogen complexed with re
2xfi  Human bace- 1 in complex with n- ((1s,2r)- 3- (((1s)- 2- ( cyclohexylamino)- 1- methyl- 2- oxoethyl)amino)- 2- hydroxy- 1- ( phenylmethyl)propyl)- 3- ((methylsulfonyl)(phenyl)amino) benzamide
2xfj  Human bace- 1 in complex with n- ((1s,2r)- 3- (((1s)- 2- ( cyclohexylamino)- 1- methyl- 2- oxoethyl)amino)- 2- hydroxy- 1- ( phenylmethyl)propyl)- 3- (ethylamino)- 5- (2- oxo- 1- pyrrolidinyl)benzamide
2xfk  Human bace- 1 in complex with n- ((1s,2r)- 3- (((1s)- 2- ( cyclohexylamino)- 1- methyl- 2- oxoethyl)amino)- 2- hydroxy- 1- ( phenylmethyl)propyl)- 3- (ethylamino)- 5- ((methylsulfonyl)( phenyl)amino)benzamide
3cyx  Crystal structure of HIV- 1 mutant i50v and inhibitor saquina
3duy  Crystal structure of human beta- secretase in complex with nvp- afj144
3dv1  Crystal structure of human beta- secretase in complex with nvp- arv999
3dv5  Crystal structure of human beta- secretase in complex with nvp- bav544
3ekp  Crystal structure of the inhibitor amprenavir (apv) in compl multi- drug resistant HIV- 1 protease variant (l10i/g48v/i54v/v64i/v82a)refer: flap+ in citation
3ekv  Crystal structure of the wild type HIV- 1 protease with the i amprenavir
3em3  Crystal structure of amprenavir (apv) in complex with a drug HIV- 1 protease variant (i50l/a71v).
3fv3  Secreted aspartic protease 1 from candida parapsilosis in co pepstatin a