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PDBsum entry 3o8y

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protein metals Protein-protein interface(s) links
Oxidoreductase PDB id
3o8y
Jmol
Contents
Protein chain
676 a.a. *
Metals
FE2 ×2
Waters ×672
* Residue conservation analysis
PDB id:
3o8y
Name: Oxidoreductase
Title: Stable-5-lipoxygenase
Structure: Arachidonate 5-lipoxygenase. Chain: a, b. Synonym: stable-5-lipoxygenase, 5-lipoxygenase, 5-lo. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: alox5, log5. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.39Å     R-factor:   0.183     R-free:   0.210
Authors: M.E.Newcomer,N.C.Gilbert,S.G.Bartlett,M.T.Waight,D.B.Neau, W.E.Boeglin,A.R.Brash
Key ref: N.C.Gilbert et al. (2011). The structure of human 5-lipoxygenase. Science, 331, 217-219. PubMed id: 21233389
Date:
03-Aug-10     Release date:   19-Jan-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P09917  (LOX5_HUMAN) -  Arachidonate 5-lipoxygenase
Seq:
Struc:
 
Seq:
Struc:
674 a.a.
676 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 13 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: E.C.1.13.11.34  - Arachidonate 5-lipoxygenase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
Leukotriene Biosynthesis
      Reaction: Arachidonate + O2 = leukotriene A4 + H2O
Arachidonate
+ O(2)
= leukotriene A(4)
+ H(2)O
      Cofactor: Fe cation
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular space   9 terms 
  Biological process     small molecule metabolic process   9 terms 
  Biochemical function     protein binding     7 terms  

 

 
    reference    
 
 
Science 331:217-219 (2011)
PubMed id: 21233389  
 
 
The structure of human 5-lipoxygenase.
N.C.Gilbert, S.G.Bartlett, M.T.Waight, D.B.Neau, W.E.Boeglin, A.R.Brash, M.E.Newcomer.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
21248314 C.D.Funk (2011).
Leukotriene inflammatory mediators meet their match.
  Sci Transl Med, 3, 66ps3.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time.