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PDBsum entry 3l5n

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protein ligands Protein-protein interface(s) links
Immune system PDB id
3l5n
Jmol
Contents
Protein chains
634 a.a. *
891 a.a. *
84 a.a. *
Ligands
NAG ×3
MAN
* Residue conservation analysis
PDB id:
3l5n
Name: Immune system
Title: Staphylococcal complement inhibitor (scin) in complex with h complement component c3b
Structure: Complement c3. Chain: a. Fragment: residues 23-667. Complement c3. Chain: b. Fragment: residues 749-1663. Staphylococcal complement inhibitor. Chain: m. Synonym: scin.
Source: Homo sapiens. Human. Organism_taxid: 9606. Staphylococcus aureus. Organism_taxid: 158878. Strain: mu50 / atcc 700699. Gene: sav1942, scn. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
7.54Å     R-factor:   0.265     R-free:   0.268
Authors: B.V.Geisbrecht,B.L.Garcia
Key ref: B.L.Garcia et al. (2010). Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b. J Mol Biol, 402, 17-29. PubMed id: 20654625 DOI: 10.1016/j.jmb.2010.07.029
Date:
22-Dec-09     Release date:   04-Aug-10    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01024  (CO3_HUMAN) -  Complement C3
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1663 a.a.
634 a.a.
Protein chain
Pfam   ArchSchema ?
P01024  (CO3_HUMAN) -  Complement C3
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1663 a.a.
891 a.a.
Protein chain
Pfam   ArchSchema ?
Q931M7  (SCIN_STAAM) -  Staphylococcal complement inhibitor
Seq:
Struc:
116 a.a.
84 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   2 terms 
  Biological process     pathogenesis   1 term 
  Biochemical function     endopeptidase inhibitor activity     1 term  

 

 
DOI no: 10.1016/j.jmb.2010.07.029 J Mol Biol 402:17-29 (2010)
PubMed id: 20654625  
 
 
Molecular basis for complement recognition and inhibition determined by crystallographic studies of the staphylococcal complement inhibitor (SCIN) bound to C3c and C3b.
B.L.Garcia, K.X.Ramyar, A.Tzekou, D.Ricklin, W.J.McWhorter, J.D.Lambris, B.V.Geisbrecht.
 
  ABSTRACT  
 
No abstract given.