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PDBsum entry 3efl

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protein ligands Protein-protein interface(s) links
Transferase PDB id
3efl
Jmol
Contents
Protein chains
286 a.a. *
263 a.a. *
Ligands
706 ×2
Waters ×142
* Residue conservation analysis
PDB id:
3efl
Name: Transferase
Title: Crystal structure of the vegfr2 kinase domain in complex wit motesanib
Structure: Vascular endothelial growth factor receptor 2. Chain: a, b. Fragment: kinase domain, unp residues 815-939, 990- 1171. Synonym: vegfr-2, kinase insert domain receptor, protein-ty kinase receptor flk-1, cd309 antigen. Engineered: yes. Mutation: yes
Source: Homo sapiens. Organism_taxid: 9606. Gene: kdr, flk1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.
Resolution:
2.20Å     R-factor:   0.230     R-free:   0.264
Authors: J.L.Kim,D.A.Whittington,A.M.Long,P.Rose,Y.Gu,H.Zhao
Key ref: A.S.Tasker and v.f.patel Discovery of motesanib. To be published, .
Date:
09-Sep-08     Release date:   15-Sep-09    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P35968  (VGFR2_HUMAN) -  Vascular endothelial growth factor receptor 2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1356 a.a.
286 a.a.*
Protein chain
Pfam   ArchSchema ?
P35968  (VGFR2_HUMAN) -  Vascular endothelial growth factor receptor 2
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1356 a.a.
263 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 9 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B: E.C.2.7.10.1  - Receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
ATP
+ [protein]-L-tyrosine
= ADP
+ [protein]-L-tyrosine phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   2 terms 
  Biological process     transmembrane receptor protein tyrosine kinase signaling pathway   3 terms 
  Biochemical function     transferase activity, transferring phosphorus-containing groups     7 terms