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1us0

Structure Title:  Human aldose reductase in complex with nadp+ and the inhibitor idd594 at 0.66 angstrom
Structure Header:  Oxidoreductase
Associated ECs:  1.1.1.21 [S]

Chains:
Code   Molecule
1.   A   Aldose reductase,  current chain [S]

Change domain classification: CATH | SCOP | Pfam


Domain Family Family Name Ligand
bound by
> 1 domain
PDB Ligand (code residue chain, name) Cognate Ligand Similarity
1. Aldo_ket_red [S] Aldo/keto reductase family N NDP 318 A, Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate  [C][S] NADPH  [R][S][L]
NADH  [R][S][L]
1
0.92
N LDT 320 A, Idd594  [C][S]
N CIT 400 A, Citric acid  [C][S] L-Arabinose  [R][S][L]
L-Arabitol  [R][S][L]
D-Xylose  [R][S][L]
Xylitol  [R][S][L]
0.53
0.53
0.53
0.53
N CIT 450 A, Citric acid  [C][S] L-Arabinose  [R][S][L]
L-Arabitol  [R][S][L]
D-Xylose  [R][S][L]
Xylitol  [R][S][L]
0.53
0.53
0.53
0.53


This page was generated for a monomeric assembly, no other alternative quaternary structural assemblies exist.