PROCOGNATE

Main Page |
Help |
Stats |
Download



1tlp

Structure Title:  Crystallographic structural analysis of phosphoramidates as inhibitors and transition-state analogs of thermolysin
Structure Header:  Hydrolase (metalloproteinase)
Associated ECs:  3.4.24.27 [S]

Chains:
Code   Molecule
1.   E   Thermolysin,  current chain [S]
2. I   Phosphoramidon

Change domain classification: CATH | SCOP | Pfam


Domain Family Family Name Ligand
bound by
> 1 domain
PDB Ligand (code residue chain, name) Cognate Ligand Similarity
1. Peptidase_M4 [S] Thermolysin metallopeptidase, catalytic domain Y RHA 1 I, 6-deoxy-mannose-1'-phosphate  [C][S]
Y ZN 5 E, Zinc ion  [C][S] Zinc  [R][S][L] 1
2. Peptidase_M4_C [S] Thermolysin metallopeptidase, alpha-helical domain N CA 1 E, Calcium ion  [C][S] Calcium  [R][S][L] 1
Y RHA 1 I, 6-deoxy-mannose-1'-phosphate  [C][S]
N CA 2 E, Calcium ion  [C][S] Calcium  [R][S][L] 1
N CA 4 E, Calcium ion  [C][S] Calcium  [R][S][L] 1
Y ZN 5 E, Zinc ion  [C][S] Zinc  [R][S][L] 1


This page was generated for a dimeric assembly, no other alternative quaternary structural assemblies exist.