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1kee

Structure Title:  Inactivation of the amidotransferase activity of carbamoyl phosphate synthetase by the antibiotic acivicin
Structure Header:  Ligase
Associated ECs:  6.3.5.5 [S]

Chains:
Code   Molecule
1.   A   Carbamoyl-phosphate synthetase large chain,  current chain [S]
2. B   Carbamoyl-phosphate synthetase small chain
3. C   Carbamoyl-phosphate synthetase large chain
4. D   Carbamoyl-phosphate synthetase small chain
5. E   Carbamoyl-phosphate synthetase large chain
6. F   Carbamoyl-phosphate synthetase small chain
7. G   Carbamoyl-phosphate synthetase large chain
8. H   Carbamoyl-phosphate synthetase small chain

Change domain classification: CATH | SCOP | Pfam


Domain Family Family Name Ligand
bound by
> 1 domain
PDB Ligand (code residue chain, name) Cognate Ligand Similarity
1. CPSase_L_chain [S] Carbamoyl-phosphate synthase L chain, N-terminal domain N NET 5012 -, Tetraethylammonium ion  [C][S]
N K 5015 -, Potassium ion  [C][S]
2. CPSase_L_D2 [S] Carbamoyl-phosphate synthase L chain, ATP binding domain N ADP 2001 A, Adenosine-5'-diphosphate  [C][S] ADP  [R][S][L] 1
N MN 2002 A, Manganese (ii) ion  [C][S]
N MN 2003 A, Manganese (ii) ion  [C][S]
N PO4 2006 A, Phosphate ion  [C][S] Orthophosphate  [R][S][L] 1
N K 5004 -, Potassium ion  [C][S]
N K 5005 -, Potassium ion  [C][S]
N K 5013 -, Potassium ion  [C][S]
N CL 5017 -, Chloride ion  [C][S]
N CL 5018 -, Chloride ion  [C][S]
3. CPSase_L_D3 [S] Carbamoyl-phosphate synthetase large chain, oligomerisation domain N CL 5020 -, Chloride ion  [C][S]
4. CPSase_L_chain [S] Carbamoyl-phosphate synthase L chain, N-terminal domain N K 5014 -, Potassium ion  [C][S]
5. CPSase_L_D2 [S] Carbamoyl-phosphate synthase L chain, ATP binding domain Y ADP 2007 A, Adenosine-5'-diphosphate  [C][S] ADP  [R][S][L] 1
6. CPSase_L_D2 [S] Carbamoyl-phosphate synthase L chain, ATP binding domain Y ADP 2007 A, Adenosine-5'-diphosphate  [C][S] ADP  [R][S][L] 1
N K 5009 A, Potassium ion  [C][S]
Y ORN 5011 -, Ornithine  [C][S] L-Glutamine  [R][S][L] 0.9
7. MGS [S] MGS-like domain Y ORN 5011 -, Ornithine  [C][S] L-Glutamine  [R][S][L] 0.9


This page was generated for a octameric assembly, no other alternative quaternary structural assemblies exist.