Fig. 1. Overall structure of the factor XIII dimer. Panel
A is the dimer looking down the two-fold axis. The domains,
activation peptide (AP), and N and C termini of one monomer are
labeled. Panel B shows one monomer, rotated 90° with the
domains, N terminus, active site (AS), and ion sites labeled.
For both views, three unique spheres are also shown: novel
ytterbium site on the dimer two-fold axis (medium gray), active
site (light gray), and main ion site (dark gray).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem