Figure 5 - full size


Figure 5.
Fig. 5. The hydrophobic core structure of domain 2 and the interface between domains 2 and 4. The drawing is based on the x-ray structure of the truncated human annexin I containing four domains (18). The main-chains of domain 2 and domain 4 (partial) are represented by blue and cyan ribbons, respectively. The residues involved in the nonnative cap and the cluster of acidic residues as well as Arg-117 in domain 2 are shown in magenta. The residues within 5 Å distance of Leu-96 are shown in yellow, and other core residues are in gray. The residues of domain 4 are in green. Hydrogen bonds are indicated by dotted lines. The amino acid numbering is according to the crystal structure of the truncated annexin I.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (1999, 274, 2971-2977) copyright 1999.