Fig. 5. The hydrophobic core structure of domain 2 and
the interface between domains 2 and 4. The drawing is based on
the x-ray structure of the truncated human annexin I containing
four domains (18). The main-chains of domain 2 and domain 4
(partial) are represented by blue and cyan ribbons,
respectively. The residues involved in the nonnative cap and the
cluster of acidic residues as well as Arg-117 in domain 2 are
shown in magenta. The residues within 5 Å distance of
Leu-96 are shown in yellow, and other core residues are in gray.
The residues of domain 4 are in green. Hydrogen bonds are
indicated by dotted lines. The amino acid numbering is according
to the crystal structure of the truncated annexin I.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem