Figure 1 - full size

 

Figure 1.
Figure 1. Overall Fold of Human Pin1(A) Ribbon representation of Pin1. Residues 1–6 and 40–44 are not visible in electron density maps and are disordered. Apostrophes distinguish the WW domain secondary structural elements from the PPIase domain's secondary structural features. Atoms are color coded for clarity (oxygen is red, nitrogen is blue, carbon is black, and sulfur is yellow). The HPO[4]^2− label reflects the possible substitution of sulfate by phosphate in phosphate-soaked crystals. Produced with MOLSCRIPT ([25]) and Raster3D ( [2]).(B) Ribbon and molecular surface representation of the Pin1 interdomain cavity. View is the same as in (A). The WW domain is orange and the PPIase domain is light blue. The dotted surface depicts the solvent-accessible surface for residues lining the interdomain cavity. The cavity presents a largely hydrophobic composite surface as indicated by the predominance of carbon atoms lining the cavity. Produced with RIBBONS ([5]).

The above figure is reprinted by permission from Cell Press: Cell (1997, 89, 875-886) copyright 1997.