Figure 6 - full size

 

Figure 6.
Figure 6. Schematic representation of the network of interactions within the catalytic center. The enzyme chloride ion is shown in interaction with some of its ligands (Arg195, Asn298 and H[2]0). The calcium ion of the enzyme structure (liganded to Asn100 and His201) and the presumed calcium ion of the inhibitor structure are involved in the interaction. (Borders around inhibitor residues are thickened.)

The above figure is reprinted by permission from Cell Press: Structure (1996, 4, 1441-1452) copyright 1996.