The overall structure of asymmetric activated FGFR1 kinase
dimer and detailed views of inter receptor contacts. (A)
Asymmetric dimer of active phosphorylated FGFR1 is shown in
ribbon diagram. Molecules E and S of the asymmetric dimer are
colored in cyan and green, respectively. (B) A detailed view of
the interface formed between kinases in the asymmetric dimer.
ATP analog (AMP-PCP) and interacting residues are shown in stick
representation and the magnesium ion is shown as a blue sphere.
Residues from molecule S are labeled with primes. The color
scheme applied in this figure is used for all figures. Secondary
structures are labeled in blue. (C) Surface representation of
molecule E is depicted in cyan with interacting residues of the
molecule S in stick and ribbon representation. Representative
residues from molecule S are labeled. (D) Surface representation
of molecule S is shown in green with interacting residues of
molecule E (Pale Cyan) in stick and ribbon representation