Figure 6: Model of GroEL/ES and RbcX-assisted folding and
assembly of Rubisco. a, Folded RbcL with a disordered
C-terminal region is transiently released from the GroEL/GroES.
b, RbcX binds to the exposed RbcL C terminus, c, RbcL dimers
are formed, ‘stapled’ together by the interaction of RbcX
with the C terminus of one RbcL and the N-terminal domain of the
adjacent subunit. d, Stable dimers assemble to
RbcL–(RbcX) complexes. e, RbcS binding weakens the
RbcL–RbcX interaction. Dissociation of RbcX and binding
of RbcS may occur in a stepwise manner, populating
intermediates. f, RbcX dissociates, enabling the C-terminal
region of RbcL to adopt its final position and allowing
maturation of Rubisco.
The above figure is reprinted
by permission from Macmillan Publishers Ltd: