Figure 5 - full size


Figure 5.
Figure 5. Surface Representations of T. maritima TF and S7
(A) Contact surfaces. The molecular surface of TF (middle) is colored by domains as in 3B but with the imprint of bound S7 colored in yellow. The dark ribbon shows S7. Molecular surfaces of S7 (outside) are rotated to display the imprint of bound TF. Blue residues contact NTD, green contact PPIase, red contact CTD, and magenta contact both NTD and CTD.
(B) Electrostatic potential of TF and S7. Molecular surfaces are oriented as in (A) and S7 is drawn as a yellow ribbon. Surfaces are colored in degrees of positive (blue) and negative (red) potential.
(C) Hydrophobic patches on the tmTF surface. Vicinal apolar atoms that form continuous hydrophobic surfaces are colored blue.
(D) Comparison of the TF:S7 interface with approximately 44,000 structurally defined interfaces between pairs of protein domains cataloged in PYBASE (Davis and Sali, 2005). Properties of the TF:S7 interface are represented by the red and blue spheres (1:1 dimer and 2:2 tetramer, respectively). PYBASE interaction sets are represented by gray spheres. Sc corresponds to shape complementarity value, BSA corresponds to buried surface area, and P/NP corresponds to the ratio of polar versus nonpolar interfacial residues.

The above figure is reprinted by permission from Cell Press: Cell (2009, 138, 923-934) copyright 2009.