Figure 7 - full size


Figure 7.
Fig. 7. Affinity maturation mutations of M18 and 1H. The M18 light chain is shown in cyan, and the M18 heavy chain in magenta. The M18 CDR loops are shown in green and labeled. PAD4 is shown in black, and the PAD4 receptor binding loops are shown in red. The L:S56P mutation occurs in both M18 and 1H and is shown as a blue ball. The adjacent residue L:Q55, which is mutated to leucine in 1H, is shown as an orange ball. The remaining M18 variant residues are shown as black balls and labeled.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2009, 387, 680-693) copyright 2009.