Figure 1 - full size

 

Figure 1.
Fig. 1. Positions of randomized residues on the binding interface of the TNF–TNFR1 complex. Mutational residues of Library I (red spheres) and Library II (orange spheres). Green cartoon represents wtTNF. White area represents the surface of the TNFR1 monomer. This binding model structure of the TNF–TNFR1 complex was constructed based on the crystal structure of the LTα–TNFR1 complex (1TNR) and that of wtTNF (1TNF).

The above figure is reprinted by permission from Elsevier: J Mol Biol (2009, 385, 1221-1229) copyright 2009.