Figure 6 - full size

 

Figure 6.
Proposed catalytic mechanism of hCAII. A schematic representation of three discrete stages of the catalytic cycle is shown. a, unbound. Note the presence of deep water (W[DW]). b, CO[2] bound. Note the displacement of W[DW] and the hydrogen bond between the substrate and backbone amide of Thr-199. c, the formation of bicarbonate. The figure was created using ChemDraw 11.0 (available from CambridgeSoft).

The above figure is reprinted from an Open Access publication published by the ASBMB: J Biol Chem (2008, 283, 30766-30771) copyright 2008.