Figure 7 - full size


Figure 7.
Figure 7. Intersubunit Bridges in the Canine Ribosome
(A) Known rotations of the body and head of the small subunit are indicated by arrows on the canine ribosome. Positions of the bridges specific to eukaryotic ribosomes and bridge 2e are indicated.
(B) A reverse view of the ribosome shows that the ebs form a contiguous line along the lateral edge of the small subunit and are also present beneath the subunits (eb11).
(C) An unmodeled C-terminal extension of L37ae contacts h22 in bridge 2e.
(D) An α helix originates from S-IV and extends across the subunit interface to form eb8. Additional density from L7ae and ES31 helps to form this bridge near the L1 stalk helix (H76).
(E) Bridge 9 (eb9) involves extensive interactions between L30e and S13e. The N-terminal helix of S13e is flipped out to interact with protein S-IX.
(F) Protein S-VII forms a bridge between ES3^S and ES41. An icon view in the lower left shows the proximity of eb11 and eb12.
(G) A C-terminal extension of L19e forms a long helix that crosses the intersubunit gap to interact with one branch of ES6^S.

The above figure is reprinted from an Open Access publication published by Cell Press: Structure (2008, 16, 535-548) copyright 2008.