Figure 3 - full size


Figure 3.
Figure 3: Inhibition of EGFR kinase activity by MIG6(segments 1–2). a, Inhibition of the L834R mutant kinase in solution by peptides 336–412 or 336–412(Y358A) (containing both segment 1 and 2). The 30-residue peptide (containing segment 1 only) is used as a control. The insert shows an expanded view at low peptide concentrations. b, Inhibition of the wild-type kinase in solution by peptides 336–412 or 336–412(Y358A). Titration of peptide 336–412 beyond 30 M leads to unreliable results owing to precipitation of the protein and peptide (see Methods).

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nature (2007, 450, 741-744) copyright 2007.