Figure 3: Inhibition of EGFR kinase activity by MIG6(segments
1–2). a, Inhibition of the L834R mutant kinase in solution
by peptides 336–412 or 336–412(Y358A) (containing both
segment 1 and 2). The 30-residue peptide (containing segment 1
only) is used as a control. The insert shows an expanded view at
low peptide concentrations. b, Inhibition of the wild-type
kinase in solution by peptides 336–412 or 336–412(Y358A).
Titration of peptide 336–412 beyond 30 M
leads to unreliable results owing to precipitation of the
protein and peptide (see Methods).
The above figure is reprinted
by permission from Macmillan Publishers Ltd: