Figure 3 - full size

 

Figure 3.
Fig. 3. Active sites. (a) HsGS active site with bound ADP, MSO-P, and manganese ions. The N-terminal β-grasp domain is in blue, whereas the C-terminal catalytic domain of the adjoining subunit is in gold. Electron density of ligands is shown by using the final SIGMAA-weighted 2m F[o] − d F[c] map contoured at 1 σ (0.26 electrons Å^−3). Conserved hydrophobic residues interacting with the adenine ring of ADP, as described in the text, are shown with ball-and-stick representations. (b) Polar interactions with ligands in the HsGS/MnADP/MSO-P structure.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2008, 375, 217-228) copyright 2008.