Figure 2. The NBD_Linker:Auxilin J Domain Complex
NBD_Linker:auxilin J Domain complex with J domain (cyan) in
ribbon representation and NBD_Linker rendered as a transparent
surface (green; with aa 383–390 in magenta) with the path of
the polypeptide chain shown as a coil and the bound nucleotide
in stick representation.
(B) Model from (A) rotated as
indicated. In yellow on the J domain are regions corresponding
to those mapped by NMR (in the polyoma virus T antigen) to be
involved in interaction with Hsc70 (Garimella et al., 2006).
(C) The region indicated by the box in (B) expanded to
identify residues important for the J domain:Hsc70 interaction.
These are labeled with white lettering on the surface of the
Hsc70, which is colored green, red, and blue for carbon, oxygen,
and nitrogen atoms, respectively, and with black lettering on
the J domain with stick representations of the side chains of
relevant J domain residues colored cyan, red, and blue for
carbon, oxygen, and nitrogen atoms, respectively.
The above figure is reprinted
from an Open Access publication published by Cell Press: