Figure 3 - full size


Figure 3.
Fig. 3. Mode of ACP binding to the central wheel and the catalytic cleft entrance of KS (gray). (A) The extended prosthetic PPT group (magenta) of ACP (cyan) reaches into the catalytic pocket of KS (asterisk). Distal to the PPT arm, ACP is flexibly tethered to the central hub (green dot) and the peripheral anchor (dashed circle) at the interior of the dome (brown). (B) Top and bottom views of ACP bound to the entrance cleft of KS via its core part and contacting the central wheel with the additional part. (C) ACP binding is mediated by complementarily charged patches, as visualized by the electrostatic surface potential of the contact areas (blue, positive; red, negative).

The above figure is reprinted by permission from the AAAs: Science (2007, 316, 288-290) copyright 2007.