Figure 4 - full size

 

Figure 4.
(a) TCR residues in contact with mutant TPI. The substituted TPI isoleucine residue (position 3) is magenta. (b) Interactions between E8 and mutant TPI. (c) Interactions between the E8 V[ ]domain and the HLA-DR1 1 -helix. (d,e) Interactions between mutant TPI isoleucine at position 3 and TCR E8 (d) or wild-type TPI threonine at position 3 and HLA-DR1 complexes (e). TCR residues are identified by one-letter amino-acid designation followed by position number and chain designation; peptide residues are identified by one-letter amino-acid designation followed by position ('P') number. Colors of TCR and MHC molecules as in Figure 3; hydrogen bonds, red dotted lines; salt bridges, solid lines; van der Waals contacts, black dotted lines.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Immunol (2007, 8, 398-408) copyright 2007.