Figure 2 - full size


Figure 2.
Figure 2. Conformational changes in MAM and TCR upon complex formation. (a) Superposition of the MAM–HLA-DR1/HA complex (green) determined in our earlier study^13 onto its counterpart (red) in the ternary complex. The MAM CTD is not included in superposition. (b) Superposition of the MAM CTD in the previous MAM–HLA-DR1/HA binary complex^13 onto its counterpart (red) in the ternary complex. (c) Superposition of the ligand-free TCR-2C (ref. 2), and TCR-2C in complexes with H-2K^b MHC I with an agonist^14 and a superagonist peptide^15, onto TCR T7 in our ternary complex. Light gray, non-CDR regions; purple, CDRs of V ; green, T7 V ; lime, free 2C; pink, 2C with agonist peptide; cyan, 2C with superagonist peptide.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Mol Biol (2007, 14, 169-171) copyright 2007.