Figure 3 - full size


Figure 3.
Figure 3 Detailed view of the PTP -CD active site. (a) Hydrogen-bonding network (blue dashes) bridging the ligand (vanadate ion, balls-and-stick representation) and the protein (sticks). (b) Side view depicting additional interactions (magenta dashes) between the ligand and polar residues in the active site. The partial covalent bond between Cys1904 and the V atom is shown as an orange dashed line. (c) Side view of a pTyr mimetic (p-ethyl phenylsulfamic acid) bound in the active site of the enzyme. Relevant hydrogen bonds are shown as colored dashes.

The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (2006, 62, 1435-1445) copyright 2006.