Fig. 5. Dynamic nature of the 14-3-3 dimers. (A) Crystal
structure of the apo- isoform looking down the
peptide binding grooves, which are labeled open and closed for
the individual monomers. (B) Superimposition of all seven closed
state 14-3-3 isoforms using only one monomer as the reference,
with shown in blue and in green.
The other 14-3-3 monomers, which have intermediate positions,
are colored transparent gray.