Figure 2. Structure of PTPA Homologs
(A) Topology of the
PTPA fold. The bimodular structure is formed by domain A
(helices 3–7) and domain B (helices 8–13).
Structural superposition of hPTPAΔ (blue), Ypa1Δ (green), and
Ypa2Δ (red), in about the same orientation as (C).
Stereo cartoon representation of the Ypa1Δ monomer. The helices
are colored with the same color code as (A).
representation of the Ypa1Δ monomer. The surface is color coded
in increasing shades of red representing conservation of the
surface residue. The left panel has the same orientation as (C),
whereas in the right panel, the Ypa1Δ monomer is rotated over
The above figure is reprinted
by permission from Cell Press: