FIGURE 3. Structural feature of PPIL1. A, overlay of the
structures of human PPIL1 (green) and human cyclophilin A (red).
B, comparison between cyclosporin A binding sites of PPIL1
(colored as in panel A) and counterpart of cyclophilin A
(white). Several secondary structure segments ( 3, 4, 5, 6) are
shown for clarity. The orientation is the same as shown in Fig.
2. Four conserved residues of PPIL1 are superimposed upon the
counterparts of cyclophilin A, which are colored red and green,
respectively. The atoms of the key residues involved in
formation of intermolecular bonds in the cyclophilin-Cyclosporin
complex are labeled in blue.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem