Figure 2 - full size

 

Figure 2.
IC[50] values for conduritol B epoxide of GCase variants. The shaded rectangle represents the range of values for the wild type ± S.D. The ^*GCase variants had little or no enzyme activity. CBE was shown in preliminary studies to be an irreversible inhibitor of all GCase variants.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2006, 281, 4242-4253) copyright 2006.