Figure 1 - full size

 

Figure 1.
Figure 1. Cartoon representation and structure of HePTP. (a) Cartoon representation of HePTP domain structure. The N-terminal domain of HePTP (cyan) includes the kinase interaction motif (KIM, pink, residues 15-30) while the C-terminal domain includes the PTP domain (orange, residues 44-339). The HePTP domain solved to high resolution is that of the PTP catalytic domain (residues 44-339). (b) Secondary structure of HePTP catalytic domain. Secondary structure elements numbered as for PTP1B. The bound phosphate ion is shown as a space-filling model in red. Four residues of the loop connecting b-strand 4 to b-strand 7 (b-strands 5 and 6 are not present in HePTP) could not be modeled and are presumably disordered. (c) PTP motifs in HePTP. The HePTP WPD loop is shown in cyan, the PTP motif phosphate-binding loop in magenta, the Q-loop in green and a-helix a0 in coral.21

The above figure is reprinted by permission from Elsevier: J Mol Biol (2005, 354, 150-163) copyright 2005.