Figure 5 - full size


Figure 5.
Figure 5. Surface representation of the endoNF homotrimer in complex with sialic acid. The molecular surface of the left trimer is colored by electrostatic potential (blue, positive; red, negative),whereas the transparent surface of the right trimer shows the underlying ribbon model. Sialic acid residues bound to the -barrel as 2,8-linked dimer and as monomer to the -prism domain of the spike are green spheres. Polymeric sialic acid could simultaneously interact with both binding sites, on the spike (yellow monomer) and the -barrel (red monomer) and be cleaved by the active site of the third subunit (blue monomer).

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nat Struct Mol Biol (2005, 12, 90-96) copyright 2005.