Figure 2 - full size


Figure 2.
ig. 2. Stereoview of the environ- ment of His87. The small lobe is indicated in red and the large lobe in blue. The inhibitor is indicated in black. (a) In the recombinant mouse C subunit, His87 of the small lobe interacts with the stble phosphoryation site of Thr197 of the large lobe and the carbonyl group of the main chain of Glu86 interacts with the side chain of Asng0. (b) In the pocine heart C subunit, His87 moves away from the phosphate of Thr197 and the side chain of Asng0 of the small lobe interacts with the carbonyl of Ala188 of the large lobe. istances are given in A.

The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (1993, 49, 381-388) copyright 1993.