Fig. 1. The active-site structure of native human carbonic anhydrase II. The conformation of the peptide chain is the same in the native enzyme
and all the metal-substituted derivatives described in this paper, but the solvent structure differs among the different substitutions. Waters
263 and 338 are sometimes referred to as the 'zinc water' and 'deep water', respectively. The structure was plotted using the coordinates
ansson, Carlsson, Svensson & Liljas (1992).
The above figure is reprinted
by permission from the IUCr:
Acta Crystallogr D Biol Crystallogr