Figure 3 - full size


Figure 3.
FIG. 3. Stereo view of AA bound within the active site of V349A/W387F oPGHS-1. The simulated annealing omit map F[o] - F[c] density contoured at 4.0 is shown in green. Carbon atoms of AA, which were originally built into the electron density, are shown in pink (atoms C-1-C-12). Carbon atoms of AA obtained from simulated annealing are shown in blue. Side chains of various amino acids that line the COX active site and contact the substrate are shown in a color scheme where carbons are gray, oxygens are red, nitrogens are dark blue, and sulfur is yellow. All of the figures were created using the program SETOR (22).

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2004, 279, 42929-42935) copyright 2004.