Figure 7. Biological Implications of the Pol λ
Structure(A) Stereo view of an overlay of the active site of Pol
λ with that of Pol β in a closed conformation (1BPY). The DNA
corresponds to the Pol λ structure, while the incoming ddCTP
(green) and metal ions (gray balls) correspond to Pol β 1BPY.
Relevant residues are shown in red (Pol λ) and blue (Pol β).
The template strand is gray and the primer terminus is
yellow.(B) Electrostatic surface potential of Pol λ and Pol β.
The DNA for each of the structures is shown in gray (template)
and yellow (primer and downstream primer). The potential ranges
from −8 kT/e (red) to 8 kT/e (blue).
The above figure is reprinted
by permission from Cell Press: