FIG. 4. N-terminal insert of human CA IV relative to human
CA XII and murine CA XIV. The CA IV sequence is depicted in red
with the side chains labeled, and the CA XII and CA XIV
sequences are shown as C traces in blue and
green, respectively. The additional intramolecular contacts in
CA IV between the N-terminal insert and the 130's loop combined
with the additional disulfide bond between Cys-6 and Cys-13
(depicted in gold) stabilize CA IV in the presence of SDS.
Inserts in the CA IV sequence are numbered according to the
point of insertion with a letter appended (e.g. 11A, 11B, etc.).
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem