Figure 2 - full size


Figure 2.
FIG. 2. Schematic drawing of the two GR structures. a, the covalently connected dimer in the GR-LBD and the antagonist RU-486. Helix 12 (yellow) from the blue subunit binds in the hydrophobic groove on the purple subunit, and then the end of the protein (in yellow) chain comes back and binds in the blue subunit. b, in GR4, the four monomers in the asymmetric unit are shown with helix 12 marked in red and the coactivator peptide TIF2 marked in light brown. c and d, two alternative dimer structures.

The above figure is reprinted by permission from the ASBMB: J Biol Chem (2003, 278, 22748-22754) copyright 2003.