Figure 2. Structures of tGA and the aGA a-domain. (a)
Stereo view of the tGA b-domain. (b) Structural correspondence
between the b-domain and linker region of tGA (left) and the
N-glycan of aGA (right). Tan and red loops are on the catalytic
side of the a-domain. Loops aL1 and aL6 of tGA that interact
with the b-domain and linker are red, as are loops that interact
with a corresponding N-glycosylation site of aGA. Catalytic
residues are blue. Acarbose in the tGA active site is gray.
Conserved N-glycosylation of fungal GAs (aGA-specific
O-glycosylation sites are not shown for clarity) is in black.
The conserved subdomain of fungal GAs consisting of helix aH10'
(previously labeled helix 11) and a b-strand hairpin is in
The above figure is reprinted
by permission from Elsevier:
J Mol Biol