Figure 2 - full size


Figure 2.
Figure 2. Structures of tGA and the aGA a-domain. (a) Stereo view of the tGA b-domain. (b) Structural correspondence between the b-domain and linker region of tGA (left) and the N-glycan of aGA (right). Tan and red loops are on the catalytic side of the a-domain. Loops aL1 and aL6 of tGA that interact with the b-domain and linker are red, as are loops that interact with a corresponding N-glycosylation site of aGA. Catalytic residues are blue. Acarbose in the tGA active site is gray. Conserved N-glycosylation of fungal GAs (aGA-specific O-glycosylation sites are not shown for clarity) is in black. The conserved subdomain of fungal GAs consisting of helix aH10' (previously labeled helix 11[5]) and a b-strand hairpin is in dark green.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2003, 327, 61-73) copyright 2003.