Figure 2 - full size


Figure 2.
Figure 2: Details of the active site. a, Binding of lisinopril to tACE (stereo representation). Selected residues are shown in a 'ball-and-stick' representation with zinc atoms in green, chloride ions in red, water molecules in purple, and lisinopril (inhibitor) in yellow. Important secondary structure elements are marked. The lisinopril, Cl2, water hydrogen bonds and zinc coordination are shown in cyan, red, purple and green dotted lines, respectively. b, Schematic view of lisinopril binding with distances marked in . The different binding subsites are labelled.

The above figure is reprinted by permission from Macmillan Publishers Ltd: Nature (2003, 421, 551-554) copyright 2003.