Figure 8 - full size

 

Figure 8.
Figure 8. Simplified view show- ing the hydrogen bonding inter- actions of the ligand with the Arg triad and the catalytic residue Asp60. (a) A sulfate molecule sub- stitutes the carboxylate group of sialic acid in unliganded TrSA, and interacts with Asp60 through two water molecules. (b) Same view in the TrSA -- DANA complex and (c) in the TrSA -- NANA complex.

The above figure is reprinted by permission from Elsevier: J Mol Biol (2003, 325, 773-784) copyright 2003.