Figure 10. Model of the hypothetical TF[PPIase]-FK506
complex (left) and comparison with the actual FKBP-FK506 complex
(right). The hypothetical TF[PPIase]-FK506 complex is based upon
the same superposition of TF[PPIase] and FKBP as in Figure 8.
Regions of FK506 and of TF[PPIase] experiencing steric clashes
are indicated by their dotted van der Waals surfaces. Blue,
residues Phe66 and Tyr93 (TF[PPIase]) that interfere with the
binding in TF[PPIase] and the corresponding Val55 and Tyr82 of
FKBP. Regions of FK506 in conflict with the binding to
TF[PPIase] are displayed in red and green, respectively, and are
colored according to Scheme 1.
The above figure is reprinted
by permission from Elsevier:
J Mol Biol