Figure 1 - full size

 

Figure 1.
Fig. 1. Schematic representation of the chloride binding site and of the interaction network with active site residues (adapted from Qian et al. 1994). The essential catalytic residues are in italics. Chloride ligands are Lys300(337), Arg172(195), Asn262(298), and H[2]O1003(525); active site residues are Glu200(233), Asp174(197), and Asp264(300) the putative catalytic water molecule H[2]O1004(cat) and His263(299). Numbers in parentheses refer to pig pancreas -amylase.

The above figure is reprinted by permission from the Protein Society: Protein Sci (2002, 11, 1435-1441) copyright 2002.