Figure 2 - full size


Figure 2.
Figure 2 Overall structure of reverse gyrase. (A) Stereo view of the molecule. The catalytic Tyr809 of the C-terminal domain is shown in red as a space-filled model, and helicase motif I (residues 78–85) in red ball-and-stick representation. The colouring of the subdomains of reverse gyrase is the same for all figures except Figures 4B and 5. (B) Side view of the molecule shown with a translucent space-filling envelope. Asterisks indicate four structural elements postulated to contact DNA: dark blue, a putative metal-binding site at the extreme N-terminus; light blue, a -hairpin (residues 201–217); green, the 'latch' subdomain H3 (residues 352–427); yellow, a Zn-finger motif (residues 584–601). The conformation of the Zn-finger as shown is uncertain due to poor electron density, and has not been included in the refined model. Maximum dimensions of the molecule are 130 70 50 Å. (C) End-on view of the molecule, with the N-terminal domain towards the front.

The above figure is reprinted from an Open Access publication published by Macmillan Publishers Ltd: EMBO J (2002, 21, 418-426) copyright 2002.