Figure 2 TcMIP is homologous to other FK506-binding proteins.
(A) Stereo view of the C[ ]trace
of TcMIP (red) superimposed with those of L. pneumophila MIP
(blue; PDB code 1FD9) and human FKBP12 (yellow; PDB code 1FKJ).
(B) Stereo close-up view of the active site of TcMIP (atom
colour code) superimposed with that of the human FKBP12 -FK506
complex (green; PDB code 1bkf) and the FKBP12 -rapamycin complex
(blue; PDB code 1c9h). Some key residues and regions of the
immunosuppressors discussed in the text are labeled.
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd: